The syndrome of polyostotic fibrous dysplasia (PFD), cutaneous pigmentation and endocrinopathy (Albright's syndrome) continuous today to remain enigmatic. Not all patient with PFD have complete syndrome. In addition to the described in Albright's
original patients, other endocrinopathies have been reported, including hyperthyroidism, acromegaly, hyperparathyroidism Cushing's syndrome, adenoma of pituitary, thyroid, parathyroid and adrenal gland, vitamine Dresistant rickets and
hypothalamic
hypogonadotrophic hypogonadism.
A 27-year-old man was found to have polyostotic fibrous dysplasia of bone, cutaneous pigmentation and acromegaly with diabetes mellitus. He started to have pain in left hip joint and it caused an alternation on his gait in 1983. X-ray study
revealed
that he had fibrous dysplasia. He gradually developed clinical feature of acromegaly. Subsequent biochemical study of growth hormone and radiologic study of the sellar confirmed the diagnosis of acromegaly. Bone biopsy and microscopic examination
of the
pituitary tumor tissue obtained through transsphenoidal procedure were reported to be fibrous dysplasia and acidophilic adenoma, respectively.
The purpose of this report is to describe a patient with incomplete Albright's syndrome with acromegaly, which is very rare and we believe this is the first case to be reported in Korean literature (J Kor Soc Endocrinol 7 : 402~108, 1992)
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